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Current Studies & Research
Resource Facilitation-Best Practices Manual for Return to Work/School

Resource Facilitation: Indiana Best Practices Manual for Return-to- Work or Return-to-School     Click on the read more button to get a link to download the full manual.  Once you… Read More

Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study)

Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study) March 10, 2015 Flora Hammond, MD (PI); Funded by National Institute on Disability and Rehabilitation Research (NIDRR).  This study… Read More

Lifestyle Management in Spinal Cord Injury

New RHI Research Study, seeking participants: Lifestyle Management in Spinal Cord Injury: This pilot study is modeled on a successful lifestyle change program conducted at the University of Pittsburgh.  Based… Read More

Brain Injury Association of America ~ The Challenge

Flora M. Hammond, M.D. is featured as one of the TBI Model Systems Researchers in the Fall Edition of the Brain Injury Association of America ‘The Challenge’ Publication. Click on… Read More

Flora M. Hammond, M.D. Joins Medical Issues Panel of BIAA /Mount Sinai TBI Rehabilitation Guidelines Project

FOR IMMEDIATE RELEASE October 24, 2014   CONTACT: Stephanie S. Hale, BAA, Marketing Public Relations and Marketing Off.: 317-329-2093 Cell: 317-626-2910 stephanie.hale@rhin.com         Flora M. Hammond, M.D.… Read More

A Multi-Center, Parallel-Group, Randomized, Double-Blind, Placebo-Controlled Trial of Amantadine Hydrochloride in the Treatment of Chronic TBI Irritability and Aggression: A Replication Study April 19th, 2010

Flora Hammond, MD (PI); Funded by National Institute for Disability and Rehabilitation Research (NIDRR).

Irritability and aggression are problems that greatly affect the lives of many people living with traumatic brain injury (TBI) and their families. There has been little research to help guide physicians on how to best treat these challenging
behaviors. Recent studies suggest that amantadine might have a new use in helping people with TBI. Amantadine is a medication that has been used for decades to treat Parkinson ’s disease, prevent viral infections, and promote
recovery from coma after brain injury. Flora Hammond, MD, Chief of Medical Affairs at Rehabilitation Hospital of Indiana, recently completed a pilot study that found amantadine reduced irritability and aggression in people suffering from brain injuries. 76 individuals with chronic TBI were enrolled in a parallel-group, randomized, double-blind, controlled trial of amantadine (n=38) versus placebo (n=38). Irritability was measured before and after treatment using the Neuropsychiatric Inventory (NPI) Irritability and Aggression Domains which measures the frequency and severity of these problems. NPI-Caregiver Distress was also measured. Mean change in NPI-I was -4.3 in the amantadine group
and -2.6 in the placebo group (p=0.0085). In the amantadine group 80.56% improved at least 3 points on the NPI-I, compared to 44.44% who improved at least 3 points in the placebo group. NPI-Aggression was also significantly
improved. However, mean change in NPI-I Caregiver Distress was not statistically significant in the amantadine group, as compared to the placebo group. Thus, amantadine appears to be a beneficial treatment for reducing the frequency and severity of irritability that accompanies chronic TBI. Based on the encouraging pilot data, a larger study with several study sites across the United States is being conducted to confirm these findings that amantadine improves
irritability and aggression often associated with brain injuries. The study is funded by a $4.2 million grant from the National Institute on Disability and Rehabilitation Research. “Many individuals with TBI and their families struggle
with irritability and aggression that impacts their day-to-day life through changes in relationships and difficulties at work,” says Dr. Hammond. “A need for assistance for these two common problems is needed. With this study we hope
to verify our findings and help individuals and caregivers cope with the behavioral effects of brain injury.”