A Community Collaboration Between IU Health and St. Vincent
Current Studies & Research
Resource Facilitation-Best Practices Manual for Return to Work/School

Resource Facilitation: Indiana Best Practices Manual for Return-to- Work or Return-to-School     Click on the read more button to get a link to download the full manual.  Once you… Read More

Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study)

Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study) March 10, 2015 Flora Hammond, MD (PI); Funded by National Institute on Disability and Rehabilitation Research (NIDRR).  This study… Read More

Lifestyle Management in Spinal Cord Injury

New RHI Research Study, seeking participants: Lifestyle Management in Spinal Cord Injury: This pilot study is modeled on a successful lifestyle change program conducted at the University of Pittsburgh.  Based… Read More

Brain Injury Association of America ~ The Challenge

Flora M. Hammond, M.D. is featured as one of the TBI Model Systems Researchers in the Fall Edition of the Brain Injury Association of America ‘The Challenge’ Publication. Click on… Read More

Flora M. Hammond, M.D. Joins Medical Issues Panel of BIAA /Mount Sinai TBI Rehabilitation Guidelines Project

FOR IMMEDIATE RELEASE October 24, 2014   CONTACT: Stephanie S. Hale, BAA, Marketing Public Relations and Marketing Off.: 317-329-2093 Cell: 317-626-2910 stephanie.hale@rhin.com         Flora M. Hammond, M.D.… Read More

An Exploration of the Hypocholinergic Hypothesis of Delirium following Traumatic Brain Injury (TBI) February 25th, 2009

Jacob T. Kean, Ph.D., Principal Investigator

Traumatic brain injury (TBI) often causes delirium (confusion and sometimes
agitation) in patients recovering from these types of events. One of the neurochemical
systems that stabilize the brain, the acetylcholine system, often becomes unbalanced
when injuries like this occur, often worsening confusion. We suspect that some drugs that
are used with these kinds of injuries create further imbalances in this system.
Currently Dr. Jacob Kean is conducting a study to determine whether a specific class of
drugs (anticholinergic) could be aggravating this imbalance in these patients. Should
this study point to a connection between some of these drugs and the imbalance of the
acetylcholine system, it could suggest better outcomes may be achieved by limiting
the use of these drugs in patients with brain injuries, including reducing confusion and
potentially enhancing the speed of recovery.