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Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study)

Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study) March 10, 2015 Flora Hammond, MD (PI); Funded by National Institute on Disability and Rehabilitation Research (NIDRR).  This study… Read More

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Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study) March 12th, 2015

Multicenter Evaluation of Memory Remediation after TBI with Donepezil (MEMRI-TBI-D Study)

March 10, 2015

Flora Hammond, MD (PI); Funded by National Institute on Disability and Rehabilitation Research (NIDRR). 

This study is a four-site, randomized, parallel design, double-blind, placebo-controlled, 10-week trial that will evaluate the effect of donepezil on treatment for functionally important verbal memory problems among 160 individuals (age 18-60 years) who sustained a complicated mild, moderate, or severe non-penetrating TBI six to 36 months prior to study participation.

STUDY PURPOSE:  

The primary aims of this study are to evaluate the effect of donepezil on verbal memory and to assess the effects of donepezil on memory-related everyday function in the target population (i.e., persons age 18-60 years with clinically important verbal memory impairments during the subacute or chronic period (i.e., 6-36 months after complicated mild, moderate, or severe non-penetrating TBI). The study also will acquire data that inform on the effects of donepezil on other aspects of cognition (i.e., attention, processing speed, executive function), neuropsychiatric symptoms, community participation, and quality of life in this population as well as on caregiver burden.

Contact:  Christy Sargent at sargentc@iupui.edu or at (317) 963-7448